Structure–activity relationship of indoline-2-carboxylic acid N-(substituted) phenylamide derivatives

JH Kwak, Y Kim, H Park, JY Jang, KK Lee, W Yi…

文献索引：Kwak, Jae-Hwan; Kim, Yoseob; Park, Hyunjeong; Jang, Jae-Yong; Lee, Keun Kuk; Yi, Wonhui; Kwak, Jeong-Ah; Park, Song-Gyu; Kim, Hwanmook; Lee, Kiho; Kang, Jong Soon; Han, Sang-Bae; Hwang, Bang Yeon; Hong, Jin Tae; Jung, Jae-Kyung; Kim, Youngsoo; Cho, Jungsook; Lee, Heesoon Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4620 - 4623

全文：HTML全文

被引用次数: 12

摘要

Chroman derivatives exhibited potent inhibitory activity of NF-κB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N- (substituted) phenylamide derivatives were synthesized to explore their inhibitory activities of NF-κB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of ...