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Synthesis and evaluation of phospholipid analogs as inhibitors of cobra venom phospholipase A2

W Yuan, RJ Berman, MH Gelb

文献索引:Yuan, Wei; Berman, Richard J.; Gelb, Michael H. Journal of the American Chemical Society, 1987 , vol. 109, # 26 p. 8071 - 8081

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被引用次数: 77

摘要

Abstract: Analogues of phospholipids that contain fluoro ketone, ketone, and alcohol replacements for the ester at the 2-position of the glycerol backbone have been prepared and analyzed as inhibitors of phospholipase Az from Naja naja naja venom. Phospholipid analogues were studied that contain two alkyl chains as well as single chain compounds that lack carbon-1 of the glycerol backbone and the attached acyl unit. Compounds that ...