Substrate Modification Approach to Achieve Efficient Resolution: Didesmethylcitalopram: A Key Intermediate for Escitalopram#

CR Elati, N Kolla, PJ Vankawala…

文献索引：Organic Process Research and Development, , vol. 11, # 2 p. 289 - 292

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被引用次数: 18

摘要

... Organic Process Research & Development. ... of citalopram (1a), initially we focused on development of a diastereomeric salt resolution process for 1a. ... After several unsuccessful synthetic approaches we established an optimum procedure to access (±)-(4) by C-alkylation of 1-(4 ...