On the Mechanism of the Copper??Catalyzed Cyclopropanation Reaction

T Rasmussen, JF Jensen, N Østergaard…

文献索引：Rasmussen, Torben; Jensen, Jakob F.; stergaard, Niels; Tanner, David; Ziegler, Tom; Norrby, Per-Ola Chemistry - A European Journal, 2002 , vol. 8, # 1 p. 177 - 184

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被引用次数: 84

摘要

Abstract The selectivity-determining step in enantioselective copper-catalyzed cyclopropanation with diazo compounds has been studied by experimental and computational methods. The addition of the very reactive metallacarbene intermediate in an early transition state to the substrate alkene is concerted but strongly asynchronous, with substantial cationic character on one alkene carbon in the neighborhood of the transition ...