Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent

…, DA Walsh, EA Sudbeck, J Finley, M Luo…

文献索引：Atigadda, Venkatram R.; Brouillette, Wayne J.; Duarte, Franco; Ali, Shoukath M.; Babu, Yarlagadda S.; Bantia, Shanta; Chand, Pooran; Chu, Naiming; Montgomery, John A.; Walsh, David A.; Sudbeck, Elise A.; Finley, James; Luo, Ming; Air, Gillian M.; Laver, Graeme W. Journal of Medicinal Chemistry, 1999 , vol. 42, # 13 p. 2332 - 2343

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被引用次数: 71

摘要

On the basis of the lead compound 4-(N-acetylamino)-3-guanidinobenzoic acid (BANA 113), which inhibits influenza A sialidase with a K i of 2.5 μM, several novel aromatic inhibitors of influenza sialidases were designed. In this study the N-acetyl group of BANA 113 was replaced with a 2-pyrrolidinone ring, which was designed in part to offer opportunities for introduction of spatially directed side chains that could potentially interact with the 4-, 5-, ...