Further Studies with the 2-Amino-1, 3-thiazol-4 (5 H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and …

…, C Hale, N Han, D Hickman, RW Hungate…

文献索引：Fotsch, Christopher; Bartberger, Michael D.; Bercot, Eric A.; Chen, Michelle; Cupples, Rod; Emery, Maury; Fretland, Jenne; Guram, Anil; Hale, Clarence; Han, Nianhe; Hickman, Dean; Hungate, Randall W.; Hayashi, Michael; Komorowski, Renee; Liu, Qingyian; Matsumoto, Guy; St. Jean Jr., David J.; Ursu, Stefania; Veniant, Murielle; Xu, Guifen; Ye, Qiuping; Yuan, Chester; Zhang, Jiandong; Zhang, Xiping; Tu, Hua; Wang, Minghan Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7953 - 7967

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被引用次数: 20

摘要

A series of compounds containing the 2-amino-1, 3-thiazol-4 (5 H)-one core were found to be potent inhibitors of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). One of our lead compounds from this series activated the human nuclear xenobiotic ...