Tetrahedron

Synthesis of a prostaglandin endoperoxide model compound and its reaction with electron transfer reagents

K Takahashi, M Kishi

文献索引：Takahashi, Kimio; Kishi, Morio Tetrahedron, 1988 , vol. 44, # 15 p. 4737 - 4746

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被引用次数: 10

摘要

5-Exo-phenyl-2, 3-dioxabicyclo [2.2. 1] heptane (4c) was synthesized as a model compound of prostaglandin endoperoxide (PGH) to mimic the bioconversion of PGH into thromboxane (TX). The reaction of (4c) with various electron transfer reagents was investigated. With the aid of a catalytic amount of ferrous ion,(4c) was successfully converted into the thromboxane B (TXB) skeleton.