Design, synthesis and biological evaluation of estradiol-PEG-linked platinum (II) hybrid molecules: comparative molecular modeling study of three distinct families of …
The synthesis of a series of 17β-estradiol-platinum (II) hybrid molecules is reported. The hybrids are made of a PEG linking chain of various length and a 2-(2′-aminoethyl) pyridine ligand. They are prepared from estrone in only 5 chemical steps with an overall yield of 22%. The length of the PEG chain does not influence the solubility of the compounds as it remains relatively constant throughout the series. MTT assays showed that the derivative with the ...
