ACS combinatorial science

Parallel solution-phase synthesis of an adenosine antibiotic analog library

O Moukha-chafiq, RC Reynolds

文献索引：Moukha-Chafiq, Omar; Reynolds, Robert C. ACS Combinatorial Science, 2013 , vol. 15, # 3 p. 147 - 152

全文：HTML全文

被引用次数: 7

摘要

A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5′-amino-5′-deoxy-2′, 3′-O- isopropylidene-adenosine 3. Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to 3, in solution-phase fashion, leading after acid-mediated hydrolysis to the targeted compounds in good yields and high purity. No marked ...