Soluble 2-substituted aminopyrido [2, 3-d] pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo …

MC Schroeder, JM Hamby, CJC Connolly…

文献索引：Schroeder; Hamby; Connolly; Grohar; Winters; Barvian; Moore; Boushelle; Crean; Kraker; Driscoll; Vincent; Elliott; Lu; Batley; Dahring; Major; Panek; Doherty; Hollis Showalter Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1915 - 1926

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被引用次数: 42

摘要

In continuing our search for medicinal agents to treat proliferative diseases, we have discovered 2-substituted aminopyrido [2, 3-d] pyrimidin-7-yl ureas as a novel class of soluble, potent, broadly active tyrosine kinase (TK) inhibitors. An efficient route was developed that enabled the synthesis of a wide variety of analogues with substitution on several positions of the template. From the lead structure 1, several series of analogues ...