Synthesis of (2-Arylethylidene) cyclobutanes by Palladium-Catalyzed Reactions of Aryl Halides with Homoallyl Alcohols Bearing a Trimethylene Group at the Allylic …
Abstract Treatment of aryl bromides with homoallyl alcohols bearing a trimethylene group at the allylic position in the presence of cesium carbonate under palladium catalysis affords (2- arylethylidene) cyclobutanes selectively. The selective formation of the alkylidenecyclobutane skeleton results from regiospecific retro-allylation of the homoallyl alcohols, which accompanies the transposition of the double bonds.
