Synthesis and Biological Activity of Novel 5-(. OMEGA.-Aryloxyalkyl) oxazole Derivatives as Brain-Derived Neurotrophic Factor Inducers

T Maekawa, N Sakai, H Tawada, K Murase…

文献索引：Maekawa, Tsuyoshi; Sakai, Nozomu; Tawada, Hiroyuki; Murase, Katsuhito; Hazama, Masatoshi; Sugiyama, Yasuo; Momose Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 5 p. 565 - 573

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被引用次数: 24

摘要

A novel series of 5-(ω-aryloxyalkyl) oxazole derivatives was prepared and their effects on brain-derived neurotrophic factor (BDNF) production were evaluated in human neuroblastoma (SK-N-SH) cells. Syntheses were performed by construction of an oxazole ring as a key reaction. Most of the 5-(ω-aryloxyalkyl) oxazole derivatives markedly increased BDNF production in SK-N-SH cells. 4-(4-Chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-[3 ...