Studies on non-thiazolidinedione antidiabetic agents. 2. Novel oxyiminoalkanoic acid derivatives as potent glucose and lipid lowering agents.

…, Y Sugiyama, H Kimura, Y Momose

文献索引：Imoto, Hiroshi; Sugiyama, Yasuo; Kimura, Hiroyuki; Momose, Yu Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 2 p. 138 - 151

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被引用次数: 26

摘要

We previously reported that (Z)-2-{4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl) methoxy] benzyloxyimino}-2-(4-phenoxyphenyl) acetic acid (3) showed potent glucose and lipid lowering effects in genetically obese and diabetic mice, KKA y. This compound also showed transcriptional activity for peroxisome proliferator-activated receptor (PPAR)-γ. We expanded on the structure–activity relationships of oxyiminoalkanoic acid derivatives based on this ...