SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl) ethyl moiety (C-region)

M Berglund, MF Dalence-Guzmán, S Skogvall…

文献索引：Berglund, Magnus; Dalence-Guzman, Maria F.; Skogvall, Staffan; Sterner, Olov Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2529 - 2540

全文：HTML全文

被引用次数: 12

摘要

Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl) ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in ...