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European journal of medicinal chemistry

Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl) phenyl] cinnamamide derivatives

KN Patel, VN Telvekar

文献索引:Patel, Kavitkumar N.; Telvekar, Vikas N. European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 43 - 56

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被引用次数: 7

摘要

Abstract The analogs of N-[4-(piperazin-1-yl) phenyl] cinnamamide were designed and synthesized by molecular hybridization approach in which part C of the designed molecule was linked through amide and carbamate functionality that improves the physicochemical properties and govern the pharmacokinetic and pharmacodynamic behavior. The systematic modification was done around the Part C to explore the structure activity relationship of ...