Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1, 2, 3-triazol-4-yl)-1, 2, 4-oxadiazol-5 (4H)-one as antifungal agents

JN Sangshetti, RR Nagawade, DB Shinde

文献索引：Sangshetti, Jaiprakash N.; Nagawade, Rahul R.; Shinde, Devanand B. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3564 - 3567

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被引用次数: 48

摘要

A novel series of 1, 2, 3 triazole compounds possessing 1, 2, 4 oxadiazole ring were efficiently synthesized. Synthesized compounds were evaluated for their in vitro antifungal activities using standard cup plate method. SAR for the series has been developed by comparing their MIC values with miconazole and fluconazole. Compound 11a from the series was more potent than miconazole against Candida albicans (MIC-20) and ...