De novo design and synthesis of HIV-1 integrase inhibitors

…, RT Kasliwal, VM Kulkarni, N Neamati

文献索引：Makhija, Mahindra T.; Kasliwal, Rajesh T.; Kulkarni, Vithal M.; Neamati, Nouri Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2317 - 2333

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被引用次数: 56

摘要

Existing AIDS therapies are out of reach for most HIV-infected people in developing countries and, where available, they are limited by their toxicity and their cost. New anti-HIV agents are needed urgently to combat emerging viral resistance and reduce the side effects associated with currently available drugs. Toward this end, LeapFrog, a de novo drug design program was used to design novel, potent, and selective inhibitors of HIV-1 ...