Synthesis of novel 5-aryl-2-thio-1, 3, 4-oxadiazoles and the study of their structure–anti-mycobacterial activities

…, N Shvets, F Kandemirli, A Dimoglo, R Reynolds

文献索引：Macaev, Fliur; Rusu, Ghenadie; Pogrebnoi, Serghei; Gudima, Alexandru; Stingaci, Eugenia; Vlad, Ludmila; Shvets, Nathaly; Kandemirli, Fatma; Dimoglo, Anatholy; Reynolds, Robert Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4842 - 4850

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被引用次数: 136

摘要

The preparation of novel 5-aryl-2-thio-1, 3, 4-oxadiazoles 4a–41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.