Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays

C Garino, T Tomita, N Pietrancosta…

文献索引：Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4275 - 4285

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被引用次数: 57

摘要

... Journal of Medicinal Chemistry. ... Introduction. As the number of cases of Alzheimer's disease (AD) rises in developed countries, the unmet medical need for disease-modifying pharmacotherapy continues to grow. Much ...