A highly active catalyst for the room??temperature amination and Suzuki coupling of aryl chlorides

JP Wolfe, SL Buchwald

文献索引：Wolfe, John P.; Buchwald, Stephen L. Angewandte Chemie - International Edition, 1999 , vol. 38, # 16 p. 2413 - 2416

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被引用次数: 730

摘要

Abstract A unique combination of steric and electronic properties appears to determine the effectiveness of phosphanyl-substituted biphenyls as ligands in palladium-catalyzed aminations and Suzuki coupling of aryl chlorides at room temperature [Eq.(1)]. The oxidative addition step is greatly accelerated, and transmetalation (or Pd− N bond formation) and reductive elimination processes are facilitated. Use of these ligands allows for Suzuki ...