Evaluation of a Series of Anticonvulsant 1, 2, 3, 4-Tetrahydroisoquinolinyl-benzamides

…, REA Stead, TO Stean, M Thompson, N Upton…

文献索引：Chan, Wai N.; Hadley, Michael S.; Harling, John D.; Herdon, Hugh J.; Orlek, Barry S.; Riley, Graham J.; Stead, Rachel E. A.; Stean, Tania O.; Thompson, Mervyn; Upton, Neil; Ward, Robert W. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2085 - 2094

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被引用次数: 6

摘要

SAR studies around a series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides, identified by high-throughput screening at the novel SB-204269 binding site, have provided compounds such as 13, 29–33 with high affinity and excellent anticonvulsant activity in animal models.