Opening or closing the lock? When reactivity is the key to biological activity

N Al??Rifai, H Rücker…

文献索引：Al-Rifai, Nafisah; Ruecker, Hannelore; Amslinger, Sabine Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15384 - 15395

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被引用次数: 15

摘要

Abstract Thiol-mediated processes play a key role to induce or inhibit inflammation proteins. Tailoring the reactivity of electrophiles can enhance the selectivity to address only certain surface cysteines. Fourteen 2′, 3, 4, 4′-tetramethoxychalcones with different α-X substituents (X= H, F, Cl, Br, I, CN, Me, p-NO 2-C 6 H 4, Ph, p-OMe-C 6 H 4, NO 2, CF 3, COOEt, COOH) were synthesized, containing the potentially electrophilic α, β-unsaturated ...