Abstract Thiol-mediated processes play a key role to induce or inhibit inflammation proteins. Tailoring the reactivity of electrophiles can enhance the selectivity to address only certain surface cysteines. Fourteen 2′, 3, 4, 4′-tetramethoxychalcones with different α-X substituents (X= H, F, Cl, Br, I, CN, Me, p-NO 2-C 6 H 4, Ph, p-OMe-C 6 H 4, NO 2, CF 3, COOEt, COOH) were synthesized, containing the potentially electrophilic α, β-unsaturated ...
