Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents

…, GT Chen, DG Wang, YQ Li, XY Wang, H Zheng

文献索引：Ling, Yong; Chen, Guang Tong; Wang, Dong Geng; Li, Yu Qin; Wang, Xin Yang; Xiao, You An; Zheng, Heng Chinese Chemical Letters, 2012 , vol. 23, # 10 p. 1141 - 1144,4

全文：HTML全文

被引用次数: 2

摘要

Novel farnesylthiosalicylic acid (FTA) derivatives 5a–m with different substituted 1, 3, 4- thiadiazoles were synthesized. Compounds 5b, 5c, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.