1, 5-Benzodioxepin derivatives as a novel class of muscarinic M 3 receptor antagonists

…, M Fujio, H Sakashita, K Inaba, K Asano, T Akira

文献索引：Sonda, Shuji; Katayama, Kenichi; Fujio, Masakazu; Sakashita, Hiroshi; Inaba, Kenichi; Asano, Kiyoshi; Akira, Toshiaki Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 925 - 931

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被引用次数: 6

摘要

The structure–activity relationships of novel 1, 5-benzodioxepin derivatives as muscarinic M1–M3 receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M3 receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.