Structure-activity relationships of pyrrole amidine antiviral antibiotics. 2. Preparation of mono-and tripyrrole derivatives of congocidine

…, B Yagen, R Mechoulam, Y Becker

文献索引：Bialer, Meir; Yagen, Boris; Mechoulam, Raphael; Becker, Yechiel Journal of Medicinal Chemistry, 1980 , vol. 23, # 10 p. 1144 - 1148

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被引用次数: 20

摘要

Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HSV DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three ...