Tetrahedron letters

Formal total synthesis of camptothecin via ring-closing metathesis strategy

SP Chavan, K Pasupathy, MS Venkatraman, RR Kale

文献索引：Chavan, Subhash P.; Pasupathy; Venkatraman; Kale, Ramesh R. Tetrahedron Letters, 2004 , vol. 45, # 37 p. 6879 - 6882

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被引用次数: 32

摘要

A formal total synthesis of camptothecin is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the ...