Synthesis and 3D-QSAR study of 1, 4-dihydropyridine derivatives as MDR cancer reverters

A Radadiya, V Khedkar, A Bavishi, H Vala…

文献索引：Radadiya, Ashish; Khedkar, Vijay; Bavishi, Abhay; Vala, Hardevsinh; Thakrar, Shailesh; Bhavsar, Dhairya; Shah, Anamik; Coutinho, Evans European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 375 - 387

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被引用次数: 12

摘要

Abstract A series of symmetrical and unsymmetrical 1, 4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compounds were evaluated for their tumor cell cytotoxicity in HL-60 tumor cells. A 3D-QSAR study using CoMFA and CoMSIA was carried out to decipher the factors governing MDR ...