Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure–activity relationships of novel dicamphanoyl-2′, 2′-dimethyldihydropyranochromone ( …

T Zhou, Q Shi, CH Chen, H Zhu, L Huang, P Ho…

文献索引：Zhou, Ting; Shi, Qian; Chen, Chin-Ho; Zhu, Hao; Huang, Li; Ho, Phong; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6678 - 6689

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被引用次数: 24

摘要

In a continued study, 23 3′ R, 4′ R-di-O-(−)-camphanoyl-2′, 2′-dimethyldihydropyrano [2, 3-f] chromone (DCP) derivatives (5–27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR-1) strain, using 2-EDCP (4) and 2-MDCP (35) as controls. New DCP analogs 5, 9, 14, and 22 exhibited potent anti-HIV activity against HIVNL4-3 ...