A series of 5-aryl-2, 4-dihydro-3H-1, 2, 4-triazole-3-thiones was prepared and evaluated for potential antidepressant activity. Members of this series were generally prepared by the alkaline ring closures of the corresponding 1-aroylthiosemicarbazides. Several members of this series were potent antagonists of both RO 4-1284-induced hypothermia and reserpine- induced ptosis in mice. In general the more active members of this series were substituted ...
![2,4-dimethyl-5-[3-(trifluoromethyl)phenyl]-1,2,4-triazole-3-thione结构式](https://image.chemsrc.com/caspic/330/110623-37-5.png)
