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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

2, 4-Dihydro-3H-1, 2, 4-triazole-3-thiones as potential antidepressant agents

JM Kane, MW Dudley, SM Sorensen…

文献索引：Kane, John M.; Dudley, Mark W.; Sorensen, Stephen M.; Miller, Francis P. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1253 - 1258

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被引用次数: 172

摘要

A series of 5-aryl-2, 4-dihydro-3H-1, 2, 4-triazole-3-thiones was prepared and evaluated for potential antidepressant activity. Members of this series were generally prepared by the alkaline ring closures of the corresponding 1-aroylthiosemicarbazides. Several members of this series were potent antagonists of both RO 4-1284-induced hypothermia and reserpine- induced ptosis in mice. In general the more active members of this series were substituted ...

1-(4-chlorobenzoyl)-2,4-dimethylthiosemicarbazide结构式

1-(4-chlorobenz...

~%

5-(4-chlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

5-(4-chlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-chlorophen...

异硫氰酸对氯苯甲酰酯结构式

异硫氰酸对氯苯甲酰酯

甲基肼结构式

~54%

5-(4-chlorophenyl)-2-methyl-1H-1,2,4-triazole-3-thione结构式

5-(4-chlorophen...

2,6-二氟苯甲酰氯结构式

2,6-二氟苯甲酰氯

~%

5-(2,6-difluorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(2,6-difluoro...

3,4-二氯苯甲酰氯结构式

3,4-二氯苯甲酰氯

~%

5-(3,4-dichlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(3,4-dichloro...

5-(4-chlorophenyl)-2-ethyl-4-methyl-1,2,4-triazol-3-one结构式

5-(4-chlorophen...

~66%

5-(4-chlorophenyl)-2-ethyl-4-methyl-1,2,4-triazole-3-thione结构式

5-(4-chlorophen...

胡椒酸酰氯结构式

胡椒酸酰氯

~%

3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(1,3-benzodioxol-5-yl)-2,4-d imethyl-结构式

3H-1,2,4-Triazo...

1-(4-methoxy-benzoyl)-2,4-dimethyl thiosemicarbazide结构式

1-(4-methoxy-be...

~%

5-(4-methoxyphenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-methoxyphe...

对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

~%

5-(4-methoxyphenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-methoxyphe...

邻氟苯甲酰氯结构式

邻氟苯甲酰氯

~%

5-(2-fluorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(2-fluorophen...

3-三氟甲基苯甲酰氯结构式

3-三氟甲基苯甲酰氯

~%

2,4-dimethyl-5-[3-(trifluoromethyl)phenyl]-1,2,4-triazole-3-thione结构式

2,4-dimethyl-5-...

1-(4-fluorobenzoyl)-2,4-dimethylthiosemicarbazide结构式

1-(4-fluorobenz...

~%

5-(4-fluorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-fluorophen...

对氟苯甲酰氯结构式

对氟苯甲酰氯

~%

5-(4-fluorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(4-fluorophen...

3-氟苯甲酰氯结构式

3-氟苯甲酰氯

~%

舒立托唑结构式

2,4-二氟苯甲酰氯结构式

2,4-二氟苯甲酰氯

~%

3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(2,4-difluorophenyl)-2,4-dim ethyl-结构式

3H-1,2,4-Triazo...

2,4-二氯苯甲酰氯结构式

2,4-二氯苯甲酰氯

~%

5-(2,4-dichlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(2,4-dichloro...

2,6-二氯苯甲酰氯结构式

2,6-二氯苯甲酰氯

~%

5-(2,6-dichlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(2,6-dichloro...

邻氯苯甲酰氯结构式

邻氯苯甲酰氯

~%

5-(2-chlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione结构式

5-(2-chlorophen...

苯甲酰氯结构式

~%

2,4-dimethyl-5-phenyl-1,2,4-triazole-3-thione结构式

2,4-dimethyl-5-...