Synthesis and antibacterial activity of N-(5-benzylthio-1, 3, 4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1, 3, 4-thiadiazol-2-yl) piperazinyl quinolone derivatives

A Foroumadi, S Emami, A Hassanzadeh…

文献索引：Foroumadi, Alireza; Emami, Saeed; Hassanzadeh, Abdolreza; Rajaee, Majid; Sokhanvar, Kazem; Moshafi, Mohammad Hassan; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4488 - 4492

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被引用次数: 115

摘要

A series of N-(5-benzylthio-1, 3, 4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1, 3, 4-thiadiazol- 2-yl) derivatives of piperazinyl quinolones was synthesized and evaluated for antibacterial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit high activity against Gram-positive bacteria; Staphylococcus aureus and Staphylococcus epidermidis, comparable or more potent than their parent N-piperazinyl ...