The Journal of Organic Chemistry

Procedures for the acylation of diethyl malonate and ethyl acetoacetate with acid chlorides using tertiary amine bases and magnesium chloride

MW Rathke, PJ Cowan

文献索引：Rathke, Michael W.; Cowan, Patrick J. Journal of Organic Chemistry, 1985 , vol. 50, # 15 p. 2622 - 2624

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被引用次数: 109

摘要

In the presence of magnesium chloride and 2 equiv of triethylamine, diethyl malonate is C- acylated in excellent yields by acid chlorides. A variety of other metal chlorides were ineffective. Similarly, ethyl acetoacetate is C-acylated by acid chlorides in the presence of magnesium chloride and 2 equiv of pyridine.