Kepner-Tregoe Decision Analysis as a Tool To Aid Route Selection. Part 2. Application to AZD7545, a PDK Inhibitor

…, D Brown, CR Firkin, SL Jenkin, B Patel…

文献索引：Moseley, Jonathan D.; Brown, David; Firkin, Catherine R.; Jenkin, Shelley L.; Patel, Bharti; Snape, Evan W. Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1044 - 1059

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被引用次数: 21

摘要

Kepner-Tregoe decision analysis was formally used as an aid to route selection, as outlined in the preceding paper. Over 40 paper routes were assessed for suitability for both immediate and longer term manufacture of AZD7545, a compound in the early stages of development. Eight routes were then investigated in full in the laboratory, and a further four in part, over a period of 3− 4 months. From this exercise, the preferred long-term ...