Asymmetric reduction of prochiral ketones using in situ generated oxazaborolidine derived from (1S, 2S, 3R, 4R)-3-amino-7, 7-dimethoxynorbornan-2-ol. An efficient …
AAM Lapis, Â de Fátima, JED Martins, VEU Costa…
文献索引：Lapis, Alexandre A. M.; De Fatima, Angelo; Martins, Jose E. D.; Costa, Valentim E. U.; Pilli, Ronaldo A. Tetrahedron Letters, 2005 , vol. 46, # 3 p. 495 - 498
Catalytic asymmetric reduction of prochiral ketones was examined in the presence of chiral oxazaborolidine catalyst prepared in situ from (1S, 2S, 3R, 4R)-3-amino-7, 7- dimethoxynorbornan-2-ol (). The optically active secondary alcohols were generally obtained in moderate to high enantiomeric excesses (ee 43–95%) and good yields (75– 94%), except for ketones bearing electron-withdrawing groups. The methodology was ...
