Bioorganic & medicinal chemistry

Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents

J Yao, J Chen, Z He, W Sun, W Xu

文献索引：Yao, Jianwen; Chen, Jing; He, Zuopeng; Sun, Wei; Xu, Wenfang Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2923 - 2929

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被引用次数: 35

摘要

A novel series of diaryl thiourea containing sorafenib derivatives 9a–t was designed and synthesized. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS. Their antiproliferative activities against HCT116 and MDA-MB- 231 cell lines, and their inhibitory activities against the phosphorylation of VEGFR were evaluated and described. Some of the compounds showed significant activities against ...