Tetrahedron

Facile and convenient synthesis of functionalized propargylic alcohols and amines: an InBr 3–Et 3 N reagent system promotes the alkynylation of aldehydes and N, O- …

N Sakai, R Kanada, M Hirasawa, T Konakahara

文献索引：Sakai, Norio; Kanada, Reiko; Hirasawa, Maki; Konakahara, Takeo Tetrahedron, 2005 , vol. 61, # 39 p. 9298 - 9304

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被引用次数: 43

摘要

The use of a novel InBr3–Et3N reagent system to promote the alkynylation of not only a variety of aromatic/heterocyclic or bulky aliphatic aldehydes but also N, O-or N, S-acetals is described. The use of N-silyl-N, O-acetals and 1-alkynes could lead to the direct production of primary propargylic amines in good yields.