Preparation of Ketones from γ-Diethylaminobutyronitrile and Aromatic Grignard Reagents and their Conversion to Diamines. Synthesis of Quinacrine Analogs1, 2
WJ Humphlett, MJ Weiss…
文献索引：Humphlett; Weiss; Hauser Journal of the American Chemical Society, 1948 , vol. 70, p. 4020,4022
It has been shown recently4 that, contrary to the general impression, the reaction of propionitrile or a higher aliphatic nitrile with phenylmagriesium bromide gives a good yield of the ketone even when only a slight excess of the Grignard reagent is employed. In the present investigation this method has been adapted to the preparation of ketones of type (111) which may be used as intermediates in the synthesis of analogs of SN 7618 (I) or ...
