Pyridazino [3, 4, 5-de] phthalazines. II. Synthesis of nitrogen-substituted derivatives

JE Francis, KJ Doebel, PM Schutte…

文献索引：Francis; Doebel; Schutte; et al. Canadian Journal of Chemistry, 1982 , vol. 60, # 10 p. 1214 - 1232

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被引用次数: 3

摘要

The synthesis of a wide variety of 9-substituted-3-oxo-3 H-2, 9-dihydropyridazino [3, 4, 5-de] phthalazines (11) was achieved by treatment of 3-substituted-3, 4-dihydro-4-oxophthalazine- 5-carboxylic esters (10) with hydrazine hydrate. These esters were prepared from 3- hydroxyphthalide-7-carboxylic acid (7) by two different routes. Under basic conditions, alkylation of 3-oxo-3 H-2, 9-dihydropyridazino [3, 4, 5-de] phthalazine (1) gave 9- ...