Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid

SF Wnuk, S Liu, CS Yuan, RT Borchardt…

文献索引：Wnuk, Stanislaw F.; Liu, Siming; Yuan, Chong-Sheng; Borchardt, Ronald T.; Robins, Morris J. Journal of Medicinal Chemistry, 1996 , vol. 39, # 21 p. 4162 - 4166

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被引用次数: 17

摘要

S-Adenosyl-l-homocysteine (AdoHcy) hydrolase has been shown to have (5'/6') hydrolytic activity with vinyl (5') or homovinyl (6') halides derived from adenosine (Ado). This hydrolytic activity is independent of its 3'-oxidative activity. The vinyl (or homovinyl) halides are converted into 5'(or 6')-carboxaldehydes by the hydrolytic activity of the enzyme, and inactivation occurs via the oxidative activity. Amide and ester derivatives of Ado-5'- ...