European Journal of Organic Chemistry

Mechanistic Dichotomy with Alkynes in the Formal Hydrohydrazination/Fischer Indolization Tandem Reaction Catalyzed by a Ph3PAuNTf2/pTSA Binary System

NT Patil, A Konala

文献索引：Patil, Nitin T.; Konala, Ashok European Journal of Organic Chemistry, 2010 , # 35 p. 6831 - 6839

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被引用次数: 16

摘要

Abstract An efficient method involving a formal hydrohydrazination/Fischer indolization tandem reaction to synthesize 2, 3-disubstituted indoles from alkynes and arylhydrazines has been developed. The approach uses a Ph 3 PAuNTf 2/pTSA· H 2 O binary catalytic system in which a very low catalyst loading of Ph 3 PAuNTf 2 (2 mol-%) is required. The reaction time is very short and, most importantly, the reaction is not sensitive to moisture. ...