Antimalarials. 1. Heterocyclic analogs of N-substituted naphthalenebisoxazines

GS Bajwa, KE Hartman, MM Joullie

文献索引：Bajwa,G.S. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 134 - 138

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被引用次数: 16

摘要

The principal aim of this investigation was the discovery of new antimalarials. Our approach involved the introduction of various structural changes in compounds which had previously displayed some antimalarial activity. In 1957, Duffm and Rollo synthesized a series of monohydroxyand dihydroxy-substituted naphthalenes by the acidcatalyzed hydrolysis of the corresponding mono-or bisoxazines. Among these compounds, 1, 6-dihydroxy-2, 5-bis ( ...