Synthesis of 1-alkyl-2-(trifluoromethyl) azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl) amines via intermediate azetidinium salts

…, C Pham The, T Van Nguyen, N De Kimpe

文献索引：De Matteis, Valeria; Van Delft, Floris L.; Jakobi, Harald; Lindell, Stephen; Tiebes, Joerg; Rutjes, Floris P. J. T. Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7527 - 7532

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被引用次数: 26

摘要

A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl) azetidines as a new class of constrained azaheterocycles was developed starting from ethyl 4, 4, 4- trifluoroacetoacetate via imination, hydride reduction, chlorination, and base-induced ring