Synthesis and antibacterial properties of novel hydrolyzable cationic amphiphiles. Incorporation of multiple head groups leads to impressive antibacterial activity
…, P Kondaiah, S Bhattacharya
文献索引：Haldar, Jayanta; Kondaiah, Paturu; Bhattacharya, Santanu Journal of Medicinal Chemistry, 2005 , vol. 48, # 11 p. 3823 - 3831
Two sets of novel multiheaded cationic amphiphiles bearing one, two, and three trimethylammonium headgroups (T1, T2, and T3) and pyridinium headgroups (P1, P2, and P3), have been synthesized and tested for antimicrobial activities against both Gram-positive and Gram-negative bacteria. The multicationic headgroups in these amphiphiles were attached covalently via scissile ester-type linkages. The results were compared with those ...
