Betulin-derived compounds as inhibitors of alphavirus replication

…, T Ahola, J Yli-Kauhaluoma, P Tammela

文献索引：Pohjala, Leena; Alakurtti, Sami; Ahola, Tero; Yli-Kauhaluoma, Jari; Tammela, Paeivi Journal of Natural Products, 2009 , vol. 72, # 11 p. 1917 - 1926

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被引用次数: 59

摘要

This paper describes inhibition of Semliki Forest virus (SFV) replication by synthetic derivatives of naturally occurring triterpenoid betulin (1). Chemical modifications were made to OH groups at C-3 and C-28 and to the C-20− C-29 double bond. A set of heterocyclic betulin derivatives was also assayed. A free or acetylated OH group at C-3 was identified as an important structural contributor for anti-SFV activity, 3, 28-di-O-acetylbetulin (4) being ...