Reformatski condensation of benzyl 2-bromopropionate with 4-~ arbomethoxybenzaldehyde , followed by dehydration afforded benzyl 2-methyl-p-carbomethoxycinnamate (4a). Hydrogenation over a Pd catalyst gave the hydrocinnamic acid 5a. Conversion to the chloromethyl (6a) and azidomethyl ketone (7a) was followed by hydrogenation to the aminomethyl ketone@ a). Direct N-alkylation by 2, 4-diamino-5-nitro-6-chloroppimidine ...
