Trimethylsilyl Cyanide in Peptide Strategies. Part III. Needlessness for complementary hydroxyl side??chain protection

MJO Anteunis, C Becu, F Becu…

文献索引：Anteunis, M.J.O.; Becu, Chr.; Becu, F. Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 2 p. 133 - 136

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被引用次数: 6

摘要

Abstract No extra side-chain protection is needed for Ser, Thr, Tyr and Cys (nor for Asp and Glu) in peptide syntheses that are mediated by TMS-CN, whereby silylesters and ethers are formed and are stable enough even during activation of carboxylic components. This allows Head-to-Tail elongation strategies and fragment condensations without recourse to additional side-chain protection except for amine and amide functionalities. Moreover, ...