Nucleosides & nucleotides

Synthesis and antiviral studies of unsaturated analogues of isomeric dideoxynucleosides

S Bera, T Mickle, V Nair

文献索引：Bera, Sanjib; Mickle, Travis; Nair, Vasu Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2379 - 2395

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被引用次数: 11

摘要

Abstract Novel isomeric dideoxynucleosides with unsaturation in the carbohydrate moiety have been synthesized. For example, isod4A was synthesized through a rearrangement reaction involving a cyclonucleoside. Support for the structures of both purine and pyrimidine d4 compounds came from UV, NMR, HRMS and single crystal X-ray data. Interestingly, the single crystal X-ray data for isod4C shows that the base is almost ...