A4 number of thiadiazolc and oxadiazole derivatives were synthesized and evaluated for oral hvpoglycemir activitv. All of the compounds were tested by single dose administration in rats and/or dogs by the oral route. Most of the derivatives exhibited some degree of activity. 5- Cvclohexyl-2-(p-tolurnesul-fonamidoj-1, 3, 4-oxadiazole was fairly potent in both rats and dogs, and on daily administration in dogs prodiicrd and maintained n hrpoglycemia. Some ...
