Selective derivatization and sequestration of ribose from a prebiotic mix

G Springsteen, GF Joyce

文献索引：Springsteen, Greg; Joyce, Gerald F. Journal of the American Chemical Society, 2004 , vol. 126, # 31 p. 9578 - 9583

全文：HTML全文

被引用次数: 80

摘要

Observations regarding the catalytic potential of RNA and the role of RNA in biology have formed the basis for the “RNA world” hypothesis, which suggests that a genetic system based on self-replicating polyribonucleotides preceded modern biology. However, attempts to devise a realistic prebiotic synthesis of nucleic acids from simple starting materials have been plagued by problems of poor chemical selectivity, lack of stereo-and regiospecificity, ...