SYNTHESIS OF 2-HALO-4, 5-DIFLUOROBENZOIC ACIDS

TF Braish, DE Fox

文献索引：Braish, Tamim F.; Fox, Darrell E. Organic Preparations and Procedures International, 1991 , vol. 23, # 5 p. 655 - 658

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被引用次数: 8

摘要

Friedel-Crafts acylation of 5 or 8 with acetyl chloride in the presence of aluminum chloride provided the acetophenones 9 (80%) and 10 (87%) respectively? Oxidation of the acetophenones with 5% bleach (Haloform Reaction9) provided the desired trihalobenzoic acid ll" and 12 in excellent yields.