Synlett

A Metal-Free, Aqueous and General Route to 1, 5-Disubstituted-1, 2, 3-triazoles:'Reversed Regioisomeric'1, 3-Dipolar Cycloaddition of Azides and Vinyl Sulfones

S Dey, D Datta, T Pathak

文献索引：Dey, Santu; Datta, Dhrubajyoti; Pathak, Tanmaya Synlett, 2011 , # 17 p. 2521 - 2524

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被引用次数: 9

摘要

Abstract A metal-free, vinyl sulfone-based synthesis of 1, 5-disubstituted-1, 2, 3-triazoles is reported for the first time. These triazoles are easily formed in a regioselective fashion by heating under reflux a mixture of a substituted vinyl sulfone and an organic azide 'on water'. This powerful and practical route has the potential to be exploited for the synthesis of complex 1, 5-disubstituted-1, 2, 3-triazoles.